diff --git a/map.typ b/map.typ new file mode 100644 index 0000000..f04db60 --- /dev/null +++ b/map.typ @@ -0,0 +1,72 @@ += Collected notes on simulation + +== Broad Overview +Simplified model of AP: + 1. Input current causes potential to reach threshold + 2. Threshold casues voltage gated ("charged protein domains") + Na+ channels to open (depol) + 3. Voltage gated K+ channels open (opening assisted by Ca) ("delayed rectifier") and flow (repol, hyperpol) +== Mechanisms + +General .mod notes: + - PARAMETERs aren't changed during the simulation, but can be set by user + - ASSIGNEDs are variables that change dynamically (like per-section voltage), + and local variables used in computation. + - STATEs are evolved via diffeq's, and are persistent between timesteps + - DERIVATIVEs are the diffeq's + - BREAKPOINT is the computation run at every timestep + - Neuron functions additively: several writes will sum (NOT FOR nonspecific) + +=== Global State (append as I read): + - `v` - membrane potential (per section) + - `e[ca|k|na]` - equilibrium potential for [Ca|K|Na] (managed by ion mechanism) + - `i[ca|k|na]` - intracellular [Ca|K|Na] level + - `ihcn` - HCN (mixed cation channels, permeable to both Na and K) + - `imcn` - nonspecific inactivation current + +=== Module Summaries +`mech/Ca.mod` +- Basic HH Ca model, writes to the calcium current +`mech/CaDynamics_E2.mod` +- Takes Ca current and uses it to determine new level of intracellular calcium +`mech/CaDynamics_E2_soma.mod` +- Same as CaDynamics_E2.mod but adapted for soma +`mech/Ca_HVA.mod` +- High-Voltage-Activation Ca channels +- Similar to Ca.mod, but with much higher maximum conductance (0.684 $"mS"/"cm"^2$ vs 0.01 $"mS"/"cm"$) +`mech/Ca_HVA_soma.mod` +- Specific soma dynamics for HVA Ca channel +`mech/Ca_LVAst.mod` +- Low-Voltage-Activation Ca channels +`mech/Ca_LVAst_soma.mod` +- Specific soma dynamics for LVA Ca Channel +`mech/hhqt.mod` +- Squid axon HH (the og model) for Ca, K, L channels in squit giant axon membrane +`mech/Ih.mod` +- HCN current +- _note: Check later if this is addressed in any of the Ca and K dynamics_ +`mech/Im.mod` +- Potassium channel current +`mech/K_Pst.mod` +- Persistent (very slowly inactivating) component of the potassium current +- Continues conducting through sustained depolarization +`mech/K_Tst.mod` +- Transient (activates rapidly during depol) +- Inactivates rapidly during repol +- Turns off quickly even if depol continues +`mech/Nap_Et2.mod` +- Persistent sodium current +`mech/NaTa_t.mod` +- Transient sodium current +`mech/NaTa_t_myel.mod` +- Transient sodium current for myelinated +`mech/NaTa_t_nor.mod` +`mech/NaTs2_t_apic.mod` +`mech/NaTs2_t.mod` +`mech/NaTs2_t_soma.mod` +`mech/SK_E2.mod` +`mech/SK_E2_soma.mod` +`mech/SKv3_1_apic.mod` +`mech/SKv3_1.mod` +`mech/SKv3_1_soma.mod` +`mech/xtra.mod`