/* Created by Language version: 7.7.0 */ /* VECTORIZED */ #define NRN_VECTORIZED 1 #include #include #include #include "mech_api.h" #undef PI #define nil 0 #define _pval pval // clang-format off #include "md1redef.h" #include "section_fwd.hpp" #include "nrniv_mf.h" #include "md2redef.h" #include "nrnconf.h" // clang-format on #include "neuron/cache/mechanism_range.hpp" static constexpr auto number_of_datum_variables = 5; static constexpr auto number_of_floating_point_variables = 9; namespace { template using _nrn_mechanism_std_vector = std::vector; using _nrn_model_sorted_token = neuron::model_sorted_token; using _nrn_mechanism_cache_range = neuron::cache::MechanismRange; using _nrn_mechanism_cache_instance = neuron::cache::MechanismInstance; using _nrn_non_owning_id_without_container = neuron::container::non_owning_identifier_without_container; template using _nrn_mechanism_field = neuron::mechanism::field; template void _nrn_mechanism_register_data_fields(Args&&... args) { neuron::mechanism::register_data_fields(std::forward(args)...); } } #if !NRNGPU #undef exp #define exp hoc_Exp #if NRN_ENABLE_ARCH_INDEP_EXP_POW #undef pow #define pow hoc_pow #endif #endif #define nrn_init _nrn_init__CaDynamics_E2 #define _nrn_initial _nrn_initial__CaDynamics_E2 #define nrn_cur _nrn_cur__CaDynamics_E2 #define _nrn_current _nrn_current__CaDynamics_E2 #define nrn_jacob _nrn_jacob__CaDynamics_E2 #define nrn_state _nrn_state__CaDynamics_E2 #define _net_receive _net_receive__CaDynamics_E2 #define states states__CaDynamics_E2 #define _threadargscomma_ _ml, _iml, _ppvar, _thread, _globals, _nt, #define _threadargsprotocomma_ Memb_list* _ml, size_t _iml, Datum* _ppvar, Datum* _thread, double* _globals, NrnThread* _nt, #define _internalthreadargsprotocomma_ _nrn_mechanism_cache_range* _ml, size_t _iml, Datum* _ppvar, Datum* _thread, double* _globals, NrnThread* _nt, #define _threadargs_ _ml, _iml, _ppvar, _thread, _globals, _nt #define _threadargsproto_ Memb_list* _ml, size_t _iml, Datum* _ppvar, Datum* _thread, double* _globals, NrnThread* _nt #define _internalthreadargsproto_ _nrn_mechanism_cache_range* _ml, size_t _iml, Datum* _ppvar, Datum* _thread, double* _globals, NrnThread* _nt /*SUPPRESS 761*/ /*SUPPRESS 762*/ /*SUPPRESS 763*/ /*SUPPRESS 765*/ extern double *hoc_getarg(int); #define t _nt->_t #define dt _nt->_dt #define gamma _ml->template fpfield<0>(_iml) #define gamma_columnindex 0 #define decay _ml->template fpfield<1>(_iml) #define decay_columnindex 1 #define depth _ml->template fpfield<2>(_iml) #define depth_columnindex 2 #define minCai _ml->template fpfield<3>(_iml) #define minCai_columnindex 3 #define ica _ml->template fpfield<4>(_iml) #define ica_columnindex 4 #define cai _ml->template fpfield<5>(_iml) #define cai_columnindex 5 #define Dcai _ml->template fpfield<6>(_iml) #define Dcai_columnindex 6 #define v _ml->template fpfield<7>(_iml) #define v_columnindex 7 #define _g _ml->template fpfield<8>(_iml) #define _g_columnindex 8 #define _ion_ica *(_ml->dptr_field<0>(_iml)) #define _p_ion_ica static_cast>(_ppvar[0]) #define _ion_cao *(_ml->dptr_field<1>(_iml)) #define _p_ion_cao static_cast>(_ppvar[1]) #define _ion_cai *(_ml->dptr_field<2>(_iml)) #define _p_ion_cai static_cast>(_ppvar[2]) #define _ion_ca_erev *_ml->dptr_field<3>(_iml) #define _style_ca *_ppvar[4].get() /* Thread safe. No static _ml, _iml or _ppvar. */ static int hoc_nrnpointerindex = -1; static _nrn_mechanism_std_vector _extcall_thread; static Prop* _extcall_prop; /* _prop_id kind of shadows _extcall_prop to allow validity checking. */ static _nrn_non_owning_id_without_container _prop_id{}; /* external NEURON variables */ /* declaration of user functions */ static int _mechtype; extern void _nrn_cacheloop_reg(int, int); extern void hoc_register_limits(int, HocParmLimits*); extern void hoc_register_units(int, HocParmUnits*); extern void nrn_promote(Prop*, int, int); #define NMODL_TEXT 1 #if NMODL_TEXT static void register_nmodl_text_and_filename(int mechtype); #endif static void _hoc_setdata(); /* connect user functions to hoc names */ static VoidFunc hoc_intfunc[] = { {"setdata_CaDynamics_E2", _hoc_setdata}, {0, 0} }; /* Direct Python call wrappers to density mechanism functions.*/ static NPyDirectMechFunc npy_direct_func_proc[] = { {0, 0} }; /* declare global and static user variables */ #define gind 0 #define _gth 0 /* some parameters have upper and lower limits */ static HocParmLimits _hoc_parm_limits[] = { {0, 0, 0} }; static HocParmUnits _hoc_parm_units[] = { {"decay_CaDynamics_E2", "ms"}, {"depth_CaDynamics_E2", "um"}, {"minCai_CaDynamics_E2", "mM"}, {0, 0} }; static double cai0 = 0; static double delta_t = 0.01; /* connect global user variables to hoc */ static DoubScal hoc_scdoub[] = { {0, 0} }; static DoubVec hoc_vdoub[] = { {0, 0, 0} }; static double _sav_indep; extern void _nrn_setdata_reg(int, void(*)(Prop*)); static void _setdata(Prop* _prop) { _extcall_prop = _prop; _prop_id = _nrn_get_prop_id(_prop); } static void _hoc_setdata() { Prop *_prop, *hoc_getdata_range(int); _prop = hoc_getdata_range(_mechtype); _setdata(_prop); hoc_retpushx(1.); } static void nrn_alloc(Prop*); static void nrn_init(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int); static void nrn_state(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int); static void nrn_cur(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int); static void nrn_jacob(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int); static int _ode_count(int); static void _ode_map(Prop*, int, neuron::container::data_handle*, neuron::container::data_handle*, double*, int); static void _ode_spec(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int); static void _ode_matsol(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int); #define _cvode_ieq _ppvar[5].literal_value() static void _ode_matsol_instance1(_internalthreadargsproto_); /* connect range variables in _p that hoc is supposed to know about */ static const char *_mechanism[] = { "7.7.0", "CaDynamics_E2", "gamma_CaDynamics_E2", "decay_CaDynamics_E2", "depth_CaDynamics_E2", "minCai_CaDynamics_E2", 0, 0, 0, 0}; static Symbol* _ca_sym; /* Used by NrnProperty */ static _nrn_mechanism_std_vector _parm_default{ 0.001734, /* gamma */ 103.091, /* decay */ 0.1, /* depth */ 0.0001, /* minCai */ }; extern Prop* need_memb(Symbol*); static void nrn_alloc(Prop* _prop) { Prop *prop_ion{}; Datum *_ppvar{}; _ppvar = nrn_prop_datum_alloc(_mechtype, 6, _prop); _nrn_mechanism_access_dparam(_prop) = _ppvar; _nrn_mechanism_cache_instance _ml_real{_prop}; auto* const _ml = &_ml_real; size_t const _iml{}; assert(_nrn_mechanism_get_num_vars(_prop) == 9); /*initialize range parameters*/ gamma = _parm_default[0]; /* 0.001734 */ decay = _parm_default[1]; /* 103.091 */ depth = _parm_default[2]; /* 0.1 */ minCai = _parm_default[3]; /* 0.0001 */ assert(_nrn_mechanism_get_num_vars(_prop) == 9); _nrn_mechanism_access_dparam(_prop) = _ppvar; /*connect ionic variables to this model*/ prop_ion = need_memb(_ca_sym); nrn_check_conc_write(_prop, prop_ion, 1); nrn_promote(prop_ion, 3, 0); _ppvar[0] = _nrn_mechanism_get_param_handle(prop_ion, 3); /* ica */ _ppvar[1] = _nrn_mechanism_get_param_handle(prop_ion, 2); /* cao */ _ppvar[2] = _nrn_mechanism_get_param_handle(prop_ion, 1); /* cai */ _ppvar[3] = _nrn_mechanism_get_param_handle(prop_ion, 0); // erev ca _ppvar[4] = {neuron::container::do_not_search, &(_nrn_mechanism_access_dparam(prop_ion)[0].literal_value())}; /* iontype for ca */ } static void _initlists(); /* some states have an absolute tolerance */ static Symbol** _atollist; static HocStateTolerance _hoc_state_tol[] = { {0, 0} }; extern Symbol* hoc_lookup(const char*); extern void _nrn_thread_reg(int, int, void(*)(Datum*)); void _nrn_thread_table_reg(int, nrn_thread_table_check_t); extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***); extern void _cvode_abstol( Symbol**, double*, int); extern "C" void _CaDynamics_E2_reg() { int _vectorized = 1; _initlists(); ion_reg("ca", -10000.); _ca_sym = hoc_lookup("ca_ion"); register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1); _mechtype = nrn_get_mechtype(_mechanism[1]); hoc_register_parm_default(_mechtype, &_parm_default); hoc_register_npy_direct(_mechtype, npy_direct_func_proc); _nrn_setdata_reg(_mechtype, _setdata); #if NMODL_TEXT register_nmodl_text_and_filename(_mechtype); #endif _nrn_mechanism_register_data_fields(_mechtype, _nrn_mechanism_field{"gamma"} /* 0 */, _nrn_mechanism_field{"decay"} /* 1 */, _nrn_mechanism_field{"depth"} /* 2 */, _nrn_mechanism_field{"minCai"} /* 3 */, _nrn_mechanism_field{"ica"} /* 4 */, _nrn_mechanism_field{"cai"} /* 5 */, _nrn_mechanism_field{"Dcai"} /* 6 */, _nrn_mechanism_field{"v"} /* 7 */, _nrn_mechanism_field{"_g"} /* 8 */, _nrn_mechanism_field{"_ion_ica", "ca_ion"} /* 0 */, _nrn_mechanism_field{"_ion_cao", "ca_ion"} /* 1 */, _nrn_mechanism_field{"_ion_cai", "ca_ion"} /* 2 */, _nrn_mechanism_field{"_ion_ca_erev", "ca_ion"} /* 3 */, _nrn_mechanism_field{"_style_ca", "#ca_ion"} /* 4 */, _nrn_mechanism_field{"_cvode_ieq", "cvodeieq"} /* 5 */); hoc_register_prop_size(_mechtype, 9, 6); hoc_register_dparam_semantics(_mechtype, 0, "ca_ion"); hoc_register_dparam_semantics(_mechtype, 1, "ca_ion"); hoc_register_dparam_semantics(_mechtype, 2, "ca_ion"); hoc_register_dparam_semantics(_mechtype, 3, "ca_ion"); hoc_register_dparam_semantics(_mechtype, 4, "#ca_ion"); hoc_register_dparam_semantics(_mechtype, 5, "cvodeieq"); nrn_writes_conc(_mechtype, 0); hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol); hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist); hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc); ivoc_help("help ?1 CaDynamics_E2 /home/qh4os/neurenv/mech/CaDynamics_E2.mod\n"); hoc_register_limits(_mechtype, _hoc_parm_limits); hoc_register_units(_mechtype, _hoc_parm_units); } static double FARADAY = 0x1.78e555060882cp+16; static int _reset; static const char *modelname = ""; static int error; static int _ninits = 0; static int _match_recurse=1; static void _modl_cleanup(){ _match_recurse=1;} static int _ode_spec1(_internalthreadargsproto_); /*static int _ode_matsol1(_internalthreadargsproto_);*/ static neuron::container::field_index _slist1[1], _dlist1[1]; static int states(_internalthreadargsproto_); /*CVODE*/ static int _ode_spec1 (_internalthreadargsproto_) {int _reset = 0; { Dcai = - ( 10000.0 ) * ( ica * gamma / ( 2.0 * FARADAY * depth ) ) - ( cai - minCai ) / decay ; } return _reset; } static int _ode_matsol1 (_internalthreadargsproto_) { Dcai = Dcai / (1. - dt*( ( - ( ( 1.0 ) ) / decay ) )) ; return 0; } /*END CVODE*/ static int states (_internalthreadargsproto_) { { cai = cai + (1. - exp(dt*(( - ( ( 1.0 ) ) / decay ))))*(- ( ( - ( 10000.0 ) )*( ( ( ( ica )*( gamma ) ) / ( 2.0 * FARADAY * depth ) ) ) - ( ( ( - minCai ) ) ) / decay ) / ( ( - ( ( 1.0 ) ) / decay ) ) - cai) ; } return 0; } static int _ode_count(int _type){ return 1;} static void _ode_spec(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type) { Datum* _ppvar; size_t _iml; _nrn_mechanism_cache_range* _ml; Node* _nd{}; double _v{}; int _cntml; _nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type}; _ml = &_lmr; _cntml = _ml_arg->_nodecount; Datum *_thread{_ml_arg->_thread}; double* _globals = nullptr; if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get(); } for (_iml = 0; _iml < _cntml; ++_iml) { _ppvar = _ml_arg->_pdata[_iml]; _nd = _ml_arg->_nodelist[_iml]; v = NODEV(_nd); ica = _ion_ica; cai = _ion_cai; _ode_spec1 (_threadargs_); _ion_cai = cai; }} static void _ode_map(Prop* _prop, int _ieq, neuron::container::data_handle* _pv, neuron::container::data_handle* _pvdot, double* _atol, int _type) { Datum* _ppvar; _ppvar = _nrn_mechanism_access_dparam(_prop); _cvode_ieq = _ieq; for (int _i=0; _i < 1; ++_i) { _pv[_i] = _nrn_mechanism_get_param_handle(_prop, _slist1[_i]); _pvdot[_i] = _nrn_mechanism_get_param_handle(_prop, _dlist1[_i]); _cvode_abstol(_atollist, _atol, _i); } _pv[0] = _p_ion_cai; } static void _ode_matsol_instance1(_internalthreadargsproto_) { _ode_matsol1 (_threadargs_); } static void _ode_matsol(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type) { Datum* _ppvar; size_t _iml; _nrn_mechanism_cache_range* _ml; Node* _nd{}; double _v{}; int _cntml; _nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type}; _ml = &_lmr; _cntml = _ml_arg->_nodecount; Datum *_thread{_ml_arg->_thread}; double* _globals = nullptr; if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get(); } for (_iml = 0; _iml < _cntml; ++_iml) { _ppvar = _ml_arg->_pdata[_iml]; _nd = _ml_arg->_nodelist[_iml]; v = NODEV(_nd); ica = _ion_ica; cai = _ion_cai; _ode_matsol_instance1(_threadargs_); }} static void initmodel(_internalthreadargsproto_) { int _i; double _save;{ } } static void nrn_init(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type){ _nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type}; auto* const _vec_v = _nt->node_voltage_storage(); auto* const _ml = &_lmr; Datum* _ppvar; Datum* _thread; Node *_nd; double _v; int* _ni; int _iml, _cntml; _ni = _ml_arg->_nodeindices; _cntml = _ml_arg->_nodecount; _thread = _ml_arg->_thread; double* _globals = nullptr; if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get(); } for (_iml = 0; _iml < _cntml; ++_iml) { _ppvar = _ml_arg->_pdata[_iml]; _v = _vec_v[_ni[_iml]]; v = _v; ica = _ion_ica; cai = _ion_cai; initmodel(_threadargs_); _ion_cai = cai; nrn_wrote_conc(_ca_sym, _ion_ca_erev, _ion_cai, _ion_cao, _style_ca); } } static double _nrn_current(_internalthreadargsprotocomma_ double _v) { double _current=0.; v=_v; { } return _current; } static void nrn_cur(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type) { _nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type}; auto const _vec_rhs = _nt->node_rhs_storage(); auto const _vec_sav_rhs = _nt->node_sav_rhs_storage(); auto const _vec_v = _nt->node_voltage_storage(); auto* const _ml = &_lmr; Datum* _ppvar; Datum* _thread; Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml; _ni = _ml_arg->_nodeindices; _cntml = _ml_arg->_nodecount; _thread = _ml_arg->_thread; double* _globals = nullptr; if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get(); } for (_iml = 0; _iml < _cntml; ++_iml) { _ppvar = _ml_arg->_pdata[_iml]; _v = _vec_v[_ni[_iml]]; } } static void nrn_jacob(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type) { _nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type}; auto const _vec_d = _nt->node_d_storage(); auto const _vec_sav_d = _nt->node_sav_d_storage(); auto* const _ml = &_lmr; Datum* _ppvar; Datum* _thread; Node *_nd; int* _ni; int _iml, _cntml; _ni = _ml_arg->_nodeindices; _cntml = _ml_arg->_nodecount; _thread = _ml_arg->_thread; double* _globals = nullptr; if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get(); } for (_iml = 0; _iml < _cntml; ++_iml) { _vec_d[_ni[_iml]] += _g; } } static void nrn_state(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type) { _nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type}; auto* const _vec_v = _nt->node_voltage_storage(); auto* const _ml = &_lmr; Datum* _ppvar; Datum* _thread; Node *_nd; double _v = 0.0; int* _ni; _ni = _ml_arg->_nodeindices; size_t _cntml = _ml_arg->_nodecount; _thread = _ml_arg->_thread; double* _globals = nullptr; if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get(); } for (size_t _iml = 0; _iml < _cntml; ++_iml) { _ppvar = _ml_arg->_pdata[_iml]; _nd = _ml_arg->_nodelist[_iml]; _v = _vec_v[_ni[_iml]]; v=_v; { ica = _ion_ica; cai = _ion_cai; { states(_threadargs_); } { } _ion_cai = cai; }} } static void terminal(){} static void _initlists(){ int _i; static int _first = 1; if (!_first) return; _slist1[0] = {cai_columnindex, 0}; _dlist1[0] = {Dcai_columnindex, 0}; _first = 0; } #if NMODL_TEXT static void register_nmodl_text_and_filename(int mech_type) { const char* nmodl_filename = "/home/qh4os/neurenv/mech/CaDynamics_E2.mod"; const char* nmodl_file_text = ":Comment : L6\n" ": Dynamics that track inside calcium concentration\n" ": modified from Destexhe et al. 1994\n" "\n" "NEURON {\n" " SUFFIX CaDynamics_E2\n" " USEION ca READ ica WRITE cai\n" " RANGE decay, gamma, minCai, depth\n" "}\n" "\n" "UNITS {\n" " (mV) = (millivolt)\n" " (mA) = (milliamp)\n" " FARADAY = (faraday) (coulombs)\n" " (molar) = (1/liter)\n" " (mM) = (millimolar)\n" " (um) = (micron)\n" "}\n" "\n" "PARAMETER {\n" " gamma = 0.001734 : percent of free calcium (not buffered)\n" " decay = 103.091390 (ms) : rate of removal of calcium\n" " depth = 0.1 (um) : depth of shell\n" " minCai = 1e-4 (mM)\n" "}\n" "\n" "ASSIGNED {ica (mA/cm2)}\n" "\n" "STATE {\n" " cai (mM)\n" " }\n" "\n" "BREAKPOINT { SOLVE states METHOD cnexp }\n" "\n" "DERIVATIVE states {\n" " cai' = -(10000)*(ica*gamma/(2*FARADAY*depth)) - (cai - minCai)/decay\n" "}\n" ; hoc_reg_nmodl_filename(mech_type, nmodl_filename); hoc_reg_nmodl_text(mech_type, nmodl_file_text); } #endif