/* Created by Language version: 7.7.0 */ /* VECTORIZED */ #define NRN_VECTORIZED 1 #include #include #include #include "mech_api.h" #undef PI #define nil 0 #include "md1redef.h" #include "section.h" #include "nrniv_mf.h" #include "md2redef.h" #if METHOD3 extern int _method3; #endif #if !NRNGPU #undef exp #define exp hoc_Exp extern double hoc_Exp(double); #endif #define nrn_init _nrn_init__SKv3_1 #define _nrn_initial _nrn_initial__SKv3_1 #define nrn_cur _nrn_cur__SKv3_1 #define _nrn_current _nrn_current__SKv3_1 #define nrn_jacob _nrn_jacob__SKv3_1 #define nrn_state _nrn_state__SKv3_1 #define _net_receive _net_receive__SKv3_1 #define rates rates__SKv3_1 #define states states__SKv3_1 #define _threadargscomma_ _p, _ppvar, _thread, _nt, #define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt, #define _threadargs_ _p, _ppvar, _thread, _nt #define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt /*SUPPRESS 761*/ /*SUPPRESS 762*/ /*SUPPRESS 763*/ /*SUPPRESS 765*/ extern double *getarg(int); /* Thread safe. No static _p or _ppvar. */ #define t _nt->_t #define dt _nt->_dt #define gSKv3_1bar _p[0] #define gSKv3_1bar_columnindex 0 #define ik _p[1] #define ik_columnindex 1 #define gSKv3_1 _p[2] #define gSKv3_1_columnindex 2 #define m _p[3] #define m_columnindex 3 #define ek _p[4] #define ek_columnindex 4 #define mInf _p[5] #define mInf_columnindex 5 #define mTau _p[6] #define mTau_columnindex 6 #define Dm _p[7] #define Dm_columnindex 7 #define v _p[8] #define v_columnindex 8 #define _g _p[9] #define _g_columnindex 9 #define _ion_ek *_ppvar[0]._pval #define _ion_ik *_ppvar[1]._pval #define _ion_dikdv *_ppvar[2]._pval #if MAC #if !defined(v) #define v _mlhv #endif #if !defined(h) #define h _mlhh #endif #endif #if defined(__cplusplus) extern "C" { #endif static int hoc_nrnpointerindex = -1; static Datum* _extcall_thread; static Prop* _extcall_prop; /* external NEURON variables */ /* declaration of user functions */ static void _hoc_rates(void); static int _mechtype; extern void _nrn_cacheloop_reg(int, int); extern void hoc_register_prop_size(int, int, int); extern void hoc_register_limits(int, HocParmLimits*); extern void hoc_register_units(int, HocParmUnits*); extern void nrn_promote(Prop*, int, int); extern Memb_func* memb_func; #define NMODL_TEXT 1 #if NMODL_TEXT static const char* nmodl_file_text; static const char* nmodl_filename; extern void hoc_reg_nmodl_text(int, const char*); extern void hoc_reg_nmodl_filename(int, const char*); #endif extern void _nrn_setdata_reg(int, void(*)(Prop*)); static void _setdata(Prop* _prop) { _extcall_prop = _prop; } static void _hoc_setdata() { Prop *_prop, *hoc_getdata_range(int); _prop = hoc_getdata_range(_mechtype); _setdata(_prop); hoc_retpushx(1.); } /* connect user functions to hoc names */ static VoidFunc hoc_intfunc[] = { "setdata_SKv3_1", _hoc_setdata, "rates_SKv3_1", _hoc_rates, 0, 0 }; /* declare global and static user variables */ /* some parameters have upper and lower limits */ static HocParmLimits _hoc_parm_limits[] = { 0,0,0 }; static HocParmUnits _hoc_parm_units[] = { "gSKv3_1bar_SKv3_1", "S/cm2", "ik_SKv3_1", "mA/cm2", "gSKv3_1_SKv3_1", "S/cm2", 0,0 }; static double delta_t = 0.01; static double m0 = 0; /* connect global user variables to hoc */ static DoubScal hoc_scdoub[] = { 0,0 }; static DoubVec hoc_vdoub[] = { 0,0,0 }; static double _sav_indep; static void nrn_alloc(Prop*); static void nrn_init(NrnThread*, _Memb_list*, int); static void nrn_state(NrnThread*, _Memb_list*, int); static void nrn_cur(NrnThread*, _Memb_list*, int); static void nrn_jacob(NrnThread*, _Memb_list*, int); static int _ode_count(int); static void _ode_map(int, double**, double**, double*, Datum*, double*, int); static void _ode_spec(NrnThread*, _Memb_list*, int); static void _ode_matsol(NrnThread*, _Memb_list*, int); #define _cvode_ieq _ppvar[3]._i static void _ode_matsol_instance1(_threadargsproto_); /* connect range variables in _p that hoc is supposed to know about */ static const char *_mechanism[] = { "7.7.0", "SKv3_1", "gSKv3_1bar_SKv3_1", 0, "ik_SKv3_1", "gSKv3_1_SKv3_1", 0, "m_SKv3_1", 0, 0}; static Symbol* _k_sym; extern Prop* need_memb(Symbol*); static void nrn_alloc(Prop* _prop) { Prop *prop_ion; double *_p; Datum *_ppvar; _p = nrn_prop_data_alloc(_mechtype, 10, _prop); /*initialize range parameters*/ gSKv3_1bar = 1.93618; _prop->param = _p; _prop->param_size = 10; _ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop); _prop->dparam = _ppvar; /*connect ionic variables to this model*/ prop_ion = need_memb(_k_sym); nrn_promote(prop_ion, 0, 1); _ppvar[0]._pval = &prop_ion->param[0]; /* ek */ _ppvar[1]._pval = &prop_ion->param[3]; /* ik */ _ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dikdv */ } static void _initlists(); /* some states have an absolute tolerance */ static Symbol** _atollist; static HocStateTolerance _hoc_state_tol[] = { 0,0 }; static void _update_ion_pointer(Datum*); extern Symbol* hoc_lookup(const char*); extern void _nrn_thread_reg(int, int, void(*)(Datum*)); extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, NrnThread*, int)); extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***); extern void _cvode_abstol( Symbol**, double*, int); void _SKv3_1_reg() { int _vectorized = 1; _initlists(); ion_reg("k", -10000.); _k_sym = hoc_lookup("k_ion"); register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1); _mechtype = nrn_get_mechtype(_mechanism[1]); _nrn_setdata_reg(_mechtype, _setdata); _nrn_thread_reg(_mechtype, 2, _update_ion_pointer); #if NMODL_TEXT hoc_reg_nmodl_text(_mechtype, nmodl_file_text); hoc_reg_nmodl_filename(_mechtype, nmodl_filename); #endif hoc_register_prop_size(_mechtype, 10, 4); hoc_register_dparam_semantics(_mechtype, 0, "k_ion"); hoc_register_dparam_semantics(_mechtype, 1, "k_ion"); hoc_register_dparam_semantics(_mechtype, 2, "k_ion"); hoc_register_dparam_semantics(_mechtype, 3, "cvodeieq"); hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol); hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist); hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc); ivoc_help("help ?1 SKv3_1 /home/qh4os/neurenv/mech/SKv3_1.mod\n"); hoc_register_limits(_mechtype, _hoc_parm_limits); hoc_register_units(_mechtype, _hoc_parm_units); } static int _reset; static char *modelname = ""; static int error; static int _ninits = 0; static int _match_recurse=1; static void _modl_cleanup(){ _match_recurse=1;} static int rates(_threadargsproto_); static int _ode_spec1(_threadargsproto_); /*static int _ode_matsol1(_threadargsproto_);*/ static int _slist1[1], _dlist1[1]; static int states(_threadargsproto_); /*CVODE*/ static int _ode_spec1 (double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) {int _reset = 0; { rates ( _threadargs_ ) ; Dm = ( mInf - m ) / mTau ; } return _reset; } static int _ode_matsol1 (double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) { rates ( _threadargs_ ) ; Dm = Dm / (1. - dt*( ( ( ( - 1.0 ) ) ) / mTau )) ; return 0; } /*END CVODE*/ static int states (double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) { { rates ( _threadargs_ ) ; m = m + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / mTau)))*(- ( ( ( mInf ) ) / mTau ) / ( ( ( ( - 1.0 ) ) ) / mTau ) - m) ; } return 0; } static int rates ( _threadargsproto_ ) { mInf = 1.0 / ( 1.0 + exp ( ( ( v - ( 18.700 ) ) / ( - 9.700 ) ) ) ) ; mTau = 0.2 * 20.000 / ( 1.0 + exp ( ( ( v - ( - 46.560 ) ) / ( - 44.140 ) ) ) ) ; return 0; } static void _hoc_rates(void) { double _r; double* _p; Datum* _ppvar; Datum* _thread; NrnThread* _nt; if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; } _thread = _extcall_thread; _nt = nrn_threads; _r = 1.; rates ( _p, _ppvar, _thread, _nt ); hoc_retpushx(_r); } static int _ode_count(int _type){ return 1;} static void _ode_spec(NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node* _nd; double _v; int _iml, _cntml; _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; v = NODEV(_nd); ek = _ion_ek; _ode_spec1 (_p, _ppvar, _thread, _nt); }} static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) { double* _p; Datum* _ppvar; int _i; _p = _pp; _ppvar = _ppd; _cvode_ieq = _ieq; for (_i=0; _i < 1; ++_i) { _pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i]; _cvode_abstol(_atollist, _atol, _i); } } static void _ode_matsol_instance1(_threadargsproto_) { _ode_matsol1 (_p, _ppvar, _thread, _nt); } static void _ode_matsol(NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node* _nd; double _v; int _iml, _cntml; _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; v = NODEV(_nd); ek = _ion_ek; _ode_matsol_instance1(_threadargs_); }} extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int); static void _update_ion_pointer(Datum* _ppvar) { nrn_update_ion_pointer(_k_sym, _ppvar, 0, 0); nrn_update_ion_pointer(_k_sym, _ppvar, 1, 3); nrn_update_ion_pointer(_k_sym, _ppvar, 2, 4); } static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) { int _i; double _save;{ m = m0; { rates ( _threadargs_ ) ; m = mInf ; } } } static void nrn_init(NrnThread* _nt, _Memb_list* _ml, int _type){ double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; double _v; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } v = _v; ek = _ion_ek; initmodel(_p, _ppvar, _thread, _nt); } } static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt, double _v){double _current=0.;v=_v;{ { gSKv3_1 = gSKv3_1bar * m ; ik = gSKv3_1 * ( v - ek ) ; } _current += ik; } return _current; } static void nrn_cur(NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } ek = _ion_ek; _g = _nrn_current(_p, _ppvar, _thread, _nt, _v + .001); { double _dik; _dik = ik; _rhs = _nrn_current(_p, _ppvar, _thread, _nt, _v); _ion_dikdv += (_dik - ik)/.001 ; } _g = (_g - _rhs)/.001; _ion_ik += ik ; #if CACHEVEC if (use_cachevec) { VEC_RHS(_ni[_iml]) -= _rhs; }else #endif { NODERHS(_nd) -= _rhs; } } } static void nrn_jacob(NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; #if CACHEVEC if (use_cachevec) { VEC_D(_ni[_iml]) += _g; }else #endif { _nd = _ml->_nodelist[_iml]; NODED(_nd) += _g; } } } static void nrn_state(NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } v=_v; { ek = _ion_ek; { states(_p, _ppvar, _thread, _nt); } }} } static void terminal(){} static void _initlists(){ double _x; double* _p = &_x; int _i; static int _first = 1; if (!_first) return; _slist1[0] = m_columnindex; _dlist1[0] = Dm_columnindex; _first = 0; } #if defined(__cplusplus) } /* extern "C" */ #endif #if NMODL_TEXT static const char* nmodl_filename = "/home/qh4os/neurenv/mech/SKv3_1.mod"; static const char* nmodl_file_text = ":Comment : L6\n" ":Reference : : Characterization of a Shaw-related potassium channel family in rat brain, The EMBO Journal, vol.11, no.7,2473-2486 (1992)\n" "\n" "NEURON {\n" " SUFFIX SKv3_1\n" " USEION k READ ek WRITE ik\n" " RANGE gSKv3_1bar, gSKv3_1, ik \n" "}\n" "\n" "UNITS {\n" " (S) = (siemens)\n" " (mV) = (millivolt)\n" " (mA) = (milliamp)\n" "}\n" "\n" "PARAMETER {\n" " gSKv3_1bar = 1.936176 (S/cm2) \n" "}\n" "\n" "ASSIGNED {\n" " v (mV)\n" " ek (mV)\n" " ik (mA/cm2)\n" " gSKv3_1 (S/cm2)\n" " mInf\n" " mTau\n" "}\n" "\n" "STATE { \n" " m\n" "}\n" "\n" "BREAKPOINT {\n" " SOLVE states METHOD cnexp\n" " gSKv3_1 = gSKv3_1bar*m\n" " ik = gSKv3_1*(v-ek)\n" "}\n" "\n" "DERIVATIVE states {\n" " rates()\n" " m' = (mInf-m)/mTau\n" "}\n" "\n" "INITIAL{\n" " rates()\n" " m = mInf\n" "}\n" "\n" "PROCEDURE rates(){\n" " UNITSOFF\n" " mInf = 1/(1+exp(((v -(18.700))/(-9.700))))\n" " mTau = 0.2*20.000/(1+exp(((v -(-46.560))/(-44.140))))\n" " UNITSON\n" "}\n" "\n" ; #endif