/* Created by Language version: 7.7.0 */ /* VECTORIZED */ #define NRN_VECTORIZED 1 #include #include #include #include "mech_api.h" #undef PI #define nil 0 #include "md1redef.h" #include "section.h" #include "nrniv_mf.h" #include "md2redef.h" #if METHOD3 extern int _method3; #endif #if !NRNGPU #undef exp #define exp hoc_Exp extern double hoc_Exp(double); #endif #define nrn_init _nrn_init__hhqt #define _nrn_initial _nrn_initial__hhqt #define nrn_cur _nrn_cur__hhqt #define _nrn_current _nrn_current__hhqt #define nrn_jacob _nrn_jacob__hhqt #define nrn_state _nrn_state__hhqt #define _net_receive _net_receive__hhqt #define rates rates__hhqt #define states states__hhqt #define _threadargscomma_ _p, _ppvar, _thread, _nt, #define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt, #define _threadargs_ _p, _ppvar, _thread, _nt #define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt /*SUPPRESS 761*/ /*SUPPRESS 762*/ /*SUPPRESS 763*/ /*SUPPRESS 765*/ extern double *getarg(int); /* Thread safe. No static _p or _ppvar. */ #define t _nt->_t #define dt _nt->_dt #define gnabar _p[0] #define gnabar_columnindex 0 #define gkbar _p[1] #define gkbar_columnindex 1 #define gl _p[2] #define gl_columnindex 2 #define el _p[3] #define el_columnindex 3 #define gna _p[4] #define gna_columnindex 4 #define gk _p[5] #define gk_columnindex 5 #define il _p[6] #define il_columnindex 6 #define m _p[7] #define m_columnindex 7 #define h _p[8] #define h_columnindex 8 #define n _p[9] #define n_columnindex 9 #define ena _p[10] #define ena_columnindex 10 #define ek _p[11] #define ek_columnindex 11 #define ina _p[12] #define ina_columnindex 12 #define ik _p[13] #define ik_columnindex 13 #define minf _p[14] #define minf_columnindex 14 #define hinf _p[15] #define hinf_columnindex 15 #define ninf _p[16] #define ninf_columnindex 16 #define mtau _p[17] #define mtau_columnindex 17 #define htau _p[18] #define htau_columnindex 18 #define ntau _p[19] #define ntau_columnindex 19 #define Dm _p[20] #define Dm_columnindex 20 #define Dh _p[21] #define Dh_columnindex 21 #define Dn _p[22] #define Dn_columnindex 22 #define v _p[23] #define v_columnindex 23 #define _g _p[24] #define _g_columnindex 24 #define _ion_ena *_ppvar[0]._pval #define _ion_ina *_ppvar[1]._pval #define _ion_dinadv *_ppvar[2]._pval #define _ion_ek *_ppvar[3]._pval #define _ion_ik *_ppvar[4]._pval #define _ion_dikdv *_ppvar[5]._pval #if MAC #if !defined(v) #define v _mlhv #endif #if !defined(h) #define h _mlhh #endif #endif #if defined(__cplusplus) extern "C" { #endif static int hoc_nrnpointerindex = -1; static Datum* _extcall_thread; static Prop* _extcall_prop; /* external NEURON variables */ extern double celsius; /* declaration of user functions */ static void _hoc_rates(void); static void _hoc_vtrap(void); static int _mechtype; extern void _nrn_cacheloop_reg(int, int); extern void hoc_register_prop_size(int, int, int); extern void hoc_register_limits(int, HocParmLimits*); extern void hoc_register_units(int, HocParmUnits*); extern void nrn_promote(Prop*, int, int); extern Memb_func* memb_func; #define NMODL_TEXT 1 #if NMODL_TEXT static const char* nmodl_file_text; static const char* nmodl_filename; extern void hoc_reg_nmodl_text(int, const char*); extern void hoc_reg_nmodl_filename(int, const char*); #endif extern void _nrn_setdata_reg(int, void(*)(Prop*)); static void _setdata(Prop* _prop) { _extcall_prop = _prop; } static void _hoc_setdata() { Prop *_prop, *hoc_getdata_range(int); _prop = hoc_getdata_range(_mechtype); _setdata(_prop); hoc_retpushx(1.); } /* connect user functions to hoc names */ static VoidFunc hoc_intfunc[] = { "setdata_hhqt", _hoc_setdata, "rates_hhqt", _hoc_rates, "vtrap_hhqt", _hoc_vtrap, 0, 0 }; #define vtrap vtrap_hhqt extern double vtrap( _threadargsprotocomma_ double , double ); /* declare global and static user variables */ /* some parameters have upper and lower limits */ static HocParmLimits _hoc_parm_limits[] = { "gl_hhqt", 0, 1e+09, "gkbar_hhqt", 0, 1e+09, "gnabar_hhqt", 0, 1e+09, 0,0,0 }; static HocParmUnits _hoc_parm_units[] = { "gnabar_hhqt", "S/cm2", "gkbar_hhqt", "S/cm2", "gl_hhqt", "S/cm2", "el_hhqt", "mV", "gna_hhqt", "S/cm2", "gk_hhqt", "S/cm2", "il_hhqt", "mA/cm2", 0,0 }; static double delta_t = 0.01; static double h0 = 0; static double m0 = 0; static double n0 = 0; /* connect global user variables to hoc */ static DoubScal hoc_scdoub[] = { 0,0 }; static DoubVec hoc_vdoub[] = { 0,0,0 }; static double _sav_indep; static void nrn_alloc(Prop*); static void nrn_init(NrnThread*, _Memb_list*, int); static void nrn_state(NrnThread*, _Memb_list*, int); static void nrn_cur(NrnThread*, _Memb_list*, int); static void nrn_jacob(NrnThread*, _Memb_list*, int); static int _ode_count(int); static void _ode_map(int, double**, double**, double*, Datum*, double*, int); static void _ode_spec(NrnThread*, _Memb_list*, int); static void _ode_matsol(NrnThread*, _Memb_list*, int); #define _cvode_ieq _ppvar[6]._i static void _ode_matsol_instance1(_threadargsproto_); /* connect range variables in _p that hoc is supposed to know about */ static const char *_mechanism[] = { "7.7.0", "hhqt", "gnabar_hhqt", "gkbar_hhqt", "gl_hhqt", "el_hhqt", 0, "gna_hhqt", "gk_hhqt", "il_hhqt", 0, "m_hhqt", "h_hhqt", "n_hhqt", 0, 0}; static Symbol* _na_sym; static Symbol* _k_sym; extern Prop* need_memb(Symbol*); static void nrn_alloc(Prop* _prop) { Prop *prop_ion; double *_p; Datum *_ppvar; _p = nrn_prop_data_alloc(_mechtype, 25, _prop); /*initialize range parameters*/ gnabar = 0.12; gkbar = 0.036; gl = 0.0003; el = -54.3; _prop->param = _p; _prop->param_size = 25; _ppvar = nrn_prop_datum_alloc(_mechtype, 7, _prop); _prop->dparam = _ppvar; /*connect ionic variables to this model*/ prop_ion = need_memb(_na_sym); nrn_promote(prop_ion, 0, 1); _ppvar[0]._pval = &prop_ion->param[0]; /* ena */ _ppvar[1]._pval = &prop_ion->param[3]; /* ina */ _ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dinadv */ prop_ion = need_memb(_k_sym); nrn_promote(prop_ion, 0, 1); _ppvar[3]._pval = &prop_ion->param[0]; /* ek */ _ppvar[4]._pval = &prop_ion->param[3]; /* ik */ _ppvar[5]._pval = &prop_ion->param[4]; /* _ion_dikdv */ } static void _initlists(); /* some states have an absolute tolerance */ static Symbol** _atollist; static HocStateTolerance _hoc_state_tol[] = { 0,0 }; static void _update_ion_pointer(Datum*); extern Symbol* hoc_lookup(const char*); extern void _nrn_thread_reg(int, int, void(*)(Datum*)); extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, NrnThread*, int)); extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***); extern void _cvode_abstol( Symbol**, double*, int); void _hhqt_reg() { int _vectorized = 1; _initlists(); ion_reg("na", -10000.); ion_reg("k", -10000.); _na_sym = hoc_lookup("na_ion"); _k_sym = hoc_lookup("k_ion"); register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1); _mechtype = nrn_get_mechtype(_mechanism[1]); _nrn_setdata_reg(_mechtype, _setdata); _nrn_thread_reg(_mechtype, 2, _update_ion_pointer); #if NMODL_TEXT hoc_reg_nmodl_text(_mechtype, nmodl_file_text); hoc_reg_nmodl_filename(_mechtype, nmodl_filename); #endif hoc_register_prop_size(_mechtype, 25, 7); hoc_register_dparam_semantics(_mechtype, 0, "na_ion"); hoc_register_dparam_semantics(_mechtype, 1, "na_ion"); hoc_register_dparam_semantics(_mechtype, 2, "na_ion"); hoc_register_dparam_semantics(_mechtype, 3, "k_ion"); hoc_register_dparam_semantics(_mechtype, 4, "k_ion"); hoc_register_dparam_semantics(_mechtype, 5, "k_ion"); hoc_register_dparam_semantics(_mechtype, 6, "cvodeieq"); hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol); hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist); hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc); ivoc_help("help ?1 hhqt /home/qh4os/neurenv/mech/hhqt.mod\n"); hoc_register_limits(_mechtype, _hoc_parm_limits); hoc_register_units(_mechtype, _hoc_parm_units); } static int _reset; static char *modelname = ""; static int error; static int _ninits = 0; static int _match_recurse=1; static void _modl_cleanup(){ _match_recurse=1;} static int rates(_threadargsprotocomma_ double); static int _ode_spec1(_threadargsproto_); /*static int _ode_matsol1(_threadargsproto_);*/ static int _slist1[3], _dlist1[3]; static int states(_threadargsproto_); /*CVODE*/ static int _ode_spec1 (double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) {int _reset = 0; { rates ( _threadargscomma_ v ) ; Dm = ( minf - m ) / mtau ; Dh = ( hinf - h ) / htau ; Dn = ( ninf - n ) / ntau ; } return _reset; } static int _ode_matsol1 (double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) { rates ( _threadargscomma_ v ) ; Dm = Dm / (1. - dt*( ( ( ( - 1.0 ) ) ) / mtau )) ; Dh = Dh / (1. - dt*( ( ( ( - 1.0 ) ) ) / htau )) ; Dn = Dn / (1. - dt*( ( ( ( - 1.0 ) ) ) / ntau )) ; return 0; } /*END CVODE*/ static int states (double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) { { rates ( _threadargscomma_ v ) ; m = m + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / mtau)))*(- ( ( ( minf ) ) / mtau ) / ( ( ( ( - 1.0 ) ) ) / mtau ) - m) ; h = h + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / htau)))*(- ( ( ( hinf ) ) / htau ) / ( ( ( ( - 1.0 ) ) ) / htau ) - h) ; n = n + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / ntau)))*(- ( ( ( ninf ) ) / ntau ) / ( ( ( ( - 1.0 ) ) ) / ntau ) - n) ; } return 0; } static int rates ( _threadargsprotocomma_ double _lv ) { double _lalpha , _lbeta , _lsum , _lq10 ; _lq10 = pow( 3.0 , ( ( celsius - 6.3 ) / 10.0 ) ) ; _lalpha = .1 * vtrap ( _threadargscomma_ - ( _lv + 40.0 ) , 10.0 ) ; _lbeta = 4.0 * exp ( - ( _lv + 65.0 ) / 18.0 ) ; _lsum = _lalpha + _lbeta ; mtau = 1.0 / ( _lq10 * _lsum ) ; minf = _lalpha / _lsum ; _lalpha = .07 * exp ( - ( _lv + 65.0 ) / 20.0 ) ; _lbeta = 1.0 / ( exp ( - ( _lv + 35.0 ) / 10.0 ) + 1.0 ) ; _lsum = _lalpha + _lbeta ; htau = 1.0 / ( _lq10 * _lsum ) ; hinf = _lalpha / _lsum ; _lalpha = .01 * vtrap ( _threadargscomma_ - ( _lv + 55.0 ) , 10.0 ) ; _lbeta = .125 * exp ( - ( _lv + 65.0 ) / 80.0 ) ; _lsum = _lalpha + _lbeta ; ntau = 1.0 / ( _lq10 * _lsum ) ; ninf = _lalpha / _lsum ; return 0; } static void _hoc_rates(void) { double _r; double* _p; Datum* _ppvar; Datum* _thread; NrnThread* _nt; if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; } _thread = _extcall_thread; _nt = nrn_threads; _r = 1.; rates ( _p, _ppvar, _thread, _nt, *getarg(1) ); hoc_retpushx(_r); } double vtrap ( _threadargsprotocomma_ double _lx , double _ly ) { double _lvtrap; if ( fabs ( _lx / _ly ) < 1e-6 ) { _lvtrap = _ly * ( 1.0 - _lx / _ly / 2.0 ) ; } else { _lvtrap = _lx / ( exp ( _lx / _ly ) - 1.0 ) ; } return _lvtrap; } static void _hoc_vtrap(void) { double _r; double* _p; Datum* _ppvar; Datum* _thread; NrnThread* _nt; if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; } _thread = _extcall_thread; _nt = nrn_threads; _r = vtrap ( _p, _ppvar, _thread, _nt, *getarg(1) , *getarg(2) ); hoc_retpushx(_r); } static int _ode_count(int _type){ return 3;} static void _ode_spec(NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node* _nd; double _v; int _iml, _cntml; _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; v = NODEV(_nd); ena = _ion_ena; ek = _ion_ek; _ode_spec1 (_p, _ppvar, _thread, _nt); }} static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) { double* _p; Datum* _ppvar; int _i; _p = _pp; _ppvar = _ppd; _cvode_ieq = _ieq; for (_i=0; _i < 3; ++_i) { _pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i]; _cvode_abstol(_atollist, _atol, _i); } } static void _ode_matsol_instance1(_threadargsproto_) { _ode_matsol1 (_p, _ppvar, _thread, _nt); } static void _ode_matsol(NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node* _nd; double _v; int _iml, _cntml; _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; v = NODEV(_nd); ena = _ion_ena; ek = _ion_ek; _ode_matsol_instance1(_threadargs_); }} extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int); static void _update_ion_pointer(Datum* _ppvar) { nrn_update_ion_pointer(_na_sym, _ppvar, 0, 0); nrn_update_ion_pointer(_na_sym, _ppvar, 1, 3); nrn_update_ion_pointer(_na_sym, _ppvar, 2, 4); nrn_update_ion_pointer(_k_sym, _ppvar, 3, 0); nrn_update_ion_pointer(_k_sym, _ppvar, 4, 3); nrn_update_ion_pointer(_k_sym, _ppvar, 5, 4); } static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) { int _i; double _save;{ h = h0; m = m0; n = n0; { rates ( _threadargscomma_ v ) ; m = minf ; h = hinf ; n = ninf ; } } } static void nrn_init(NrnThread* _nt, _Memb_list* _ml, int _type){ double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; double _v; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } v = _v; ena = _ion_ena; ek = _ion_ek; initmodel(_p, _ppvar, _thread, _nt); } } static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt, double _v){double _current=0.;v=_v;{ { gna = gnabar * m * m * m * h ; ina = gna * ( v - ena ) ; gk = gkbar * n * n * n * n ; ik = gk * ( v - ek ) ; il = gl * ( v - el ) ; } _current += ina; _current += ik; _current += il; } return _current; } static void nrn_cur(NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } ena = _ion_ena; ek = _ion_ek; _g = _nrn_current(_p, _ppvar, _thread, _nt, _v + .001); { double _dik; double _dina; _dina = ina; _dik = ik; _rhs = _nrn_current(_p, _ppvar, _thread, _nt, _v); _ion_dinadv += (_dina - ina)/.001 ; _ion_dikdv += (_dik - ik)/.001 ; } _g = (_g - _rhs)/.001; _ion_ina += ina ; _ion_ik += ik ; #if CACHEVEC if (use_cachevec) { VEC_RHS(_ni[_iml]) -= _rhs; }else #endif { NODERHS(_nd) -= _rhs; } } } static void nrn_jacob(NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; #if CACHEVEC if (use_cachevec) { VEC_D(_ni[_iml]) += _g; }else #endif { _nd = _ml->_nodelist[_iml]; NODED(_nd) += _g; } } } static void nrn_state(NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } v=_v; { ena = _ion_ena; ek = _ion_ek; { states(_p, _ppvar, _thread, _nt); } }} } static void terminal(){} static void _initlists(){ double _x; double* _p = &_x; int _i; static int _first = 1; if (!_first) return; _slist1[0] = m_columnindex; _dlist1[0] = Dm_columnindex; _slist1[1] = h_columnindex; _dlist1[1] = Dh_columnindex; _slist1[2] = n_columnindex; _dlist1[2] = Dn_columnindex; _first = 0; } #if defined(__cplusplus) } /* extern "C" */ #endif #if NMODL_TEXT static const char* nmodl_filename = "/home/qh4os/neurenv/mech/hhqt.mod"; static const char* nmodl_file_text = "COMMENT\n" " This is the original Hodgkin-Huxley treatment for the set of sodium, \n" " potassium, and leakage channels found in the squid giant axon membrane.\n" " (\"A quantitative description of membrane current and its application \n" " conduction and excitation in nerve\" J.Physiol. (Lond.) 117:500-544 (1952).)\n" " Membrane voltage is in absolute mV and has been reversed in polarity\n" " from the original HH convention and shifted to reflect a resting potential\n" " of -65 mV.\n" " Remember to set a squid-appropriate temperature\n" " (e.g. in HOC: \"celsius=6.3\" or in Python: \"h.celsius=6.3\").\n" " See squid.hoc for an example of a simulation using this model.\n" " SW Jaslove 6 March, 1992\n" "ENDCOMMENT\n" "\n" "NEURON {\n" " SUFFIX hhqt\n" " USEION na READ ena WRITE ina\n" " USEION k READ ek WRITE ik\n" " NONSPECIFIC_CURRENT il\n" " RANGE gnabar, gkbar, gl, el, gna, gk\n" "}\n" " \n" "UNITS {\n" " (mA) = (milliamp)\n" " (mV) = (millivolt)\n" " (S) = (siemens)\n" "}\n" " \n" "PARAMETER {\n" " gnabar = .12 (S/cm2) <0,1e9>\n" " gkbar = .036 (S/cm2) <0,1e9>\n" " gl = .0003 (S/cm2) <0,1e9>\n" " el = -54.3 (mV)\n" "}\n" " \n" "ASSIGNED {\n" " v (mV)\n" " ena (mV)\n" " ek (mV)\n" " gna (S/cm2)\n" " gk (S/cm2)\n" " ina (mA/cm2)\n" " ik (mA/cm2)\n" " il (mA/cm2)\n" " minf hinf ninf\n" " mtau (ms) htau (ms) ntau (ms)\n" " celsius (degC)\n" "}\n" " \n" "STATE {\n" " m h n\n" "}\n" " \n" "BREAKPOINT {\n" " SOLVE states METHOD cnexp\n" " gna = gnabar*m*m*m*h\n" " ina = gna*(v - ena)\n" " gk = gkbar*n*n*n*n\n" " ik = gk*(v - ek) \n" " il = gl*(v - el)\n" "}\n" "\n" "DERIVATIVE states { \n" " rates(v)\n" " m' = (minf-m)/mtau\n" " h' = (hinf-h)/htau\n" " n' = (ninf-n)/ntau\n" "}\n" " \n" "INITIAL {\n" " rates(v)\n" " m = minf\n" " h = hinf\n" " n = ninf\n" "}\n" "\n" "PROCEDURE rates(v(mV)) { :Computes rate and other constants at current v.\n" " :Call once from HOC to initialize inf at resting v.\n" " LOCAL alpha, beta, sum, q10\n" " q10 = 3^((celsius - 6.3)/10)\n" "\n" "UNITSOFF\n" " :\"m\" sodium activation system\n" " alpha = .1*vtrap(-(v+40),10)\n" " beta = 4*exp(-(v+65)/18)\n" " sum = alpha + beta\n" " mtau = 1/(q10*sum)\n" " minf = alpha/sum\n" " \n" " :\"h\" sodium inactivation system\n" " alpha = .07*exp(-(v+65)/20)\n" " beta = 1/(exp(-(v+35)/10) + 1)\n" " sum = alpha + beta\n" " htau = 1/(q10*sum)\n" " hinf = alpha/sum\n" " \n" " :\"n\" potassium activation system\n" " alpha = .01*vtrap(-(v+55),10) \n" " beta = .125*exp(-(v+65)/80)\n" " sum = alpha + beta\n" " ntau = 1/(q10*sum)\n" " ninf = alpha/sum\n" "}\n" " \n" "FUNCTION vtrap(x,y) { :Traps for 0 in denominator of rate eqns.\n" " if (fabs(x/y) < 1e-6) {\n" " vtrap = y*(1 - x/y/2)\n" " }else{\n" " vtrap = x/(exp(x/y) - 1)\n" " }\n" "}\n" " \n" "UNITSON\n" ; #endif