75 lines
1.3 KiB
Modula-2
75 lines
1.3 KiB
Modula-2
:Comment : L6
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:Comment : The persistent component of the K current
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:Reference : : Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats:subtypes and gradients,Korngreen and Sakmann, J. Physiology, 2000
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:Comment : shifted -10 mv to correct for junction potential
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:Comment: corrected rates using q10 = 2.3, target temperature 35, orginal 21
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: **Modified to use 'celsius' for temperature to correct rates by Aman Aberra**
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NEURON {
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SUFFIX K_Pst
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USEION k READ ek WRITE ik
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RANGE gK_Pstbar, gK_Pst, ik, celsius
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}
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UNITS {
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(S) = (siemens)
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(mV) = (millivolt)
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(mA) = (milliamp)
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}
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PARAMETER {
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gK_Pstbar = 0.957198 (S/cm2)
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celsius = 35
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}
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ASSIGNED {
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v (mV)
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ek (mV)
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ik (mA/cm2)
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gK_Pst (S/cm2)
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mInf
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mTau
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hInf
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hTau
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}
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STATE {
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m
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h
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}
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BREAKPOINT {
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SOLVE states METHOD cnexp
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gK_Pst = gK_Pstbar*m*m*h
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ik = gK_Pst*(v-ek)
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}
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DERIVATIVE states {
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rates()
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m' = (mInf-m)/mTau
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h' = (hInf-h)/hTau
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}
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INITIAL{
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rates()
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m = mInf
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h = hInf
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}
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PROCEDURE rates(){
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LOCAL qt
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qt = 2.3^((celsius-21)/10)
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UNITSOFF
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v = v + 10
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mInf = (1/(1 + exp(-(v+1)/12)))
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if(v<-50){
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mTau = (1.25+175.03*exp(-v * -0.026))/qt
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}else{
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mTau = ((1.25+13*exp(-v*0.026)))/qt
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}
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hInf = 1/(1 + exp(-(v+54)/-11))
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hTau = (360+(1010+24*(v+55))*exp(-((v+75)/48)^2))/qt
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v = v - 10
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UNITSON
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}
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