neurenv/mech/x86_64/CaDynamics_E2.cpp
2026-07-11 18:20:01 -04:00

526 lines
19 KiB
C++

/* Created by Language version: 7.7.0 */
/* VECTORIZED */
#define NRN_VECTORIZED 1
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "mech_api.h"
#undef PI
#define nil 0
#define _pval pval
// clang-format off
#include "md1redef.h"
#include "section_fwd.hpp"
#include "nrniv_mf.h"
#include "md2redef.h"
#include "nrnconf.h"
// clang-format on
#include "neuron/cache/mechanism_range.hpp"
static constexpr auto number_of_datum_variables = 5;
static constexpr auto number_of_floating_point_variables = 9;
namespace {
template <typename T>
using _nrn_mechanism_std_vector = std::vector<T>;
using _nrn_model_sorted_token = neuron::model_sorted_token;
using _nrn_mechanism_cache_range = neuron::cache::MechanismRange<number_of_floating_point_variables, number_of_datum_variables>;
using _nrn_mechanism_cache_instance = neuron::cache::MechanismInstance<number_of_floating_point_variables, number_of_datum_variables>;
using _nrn_non_owning_id_without_container = neuron::container::non_owning_identifier_without_container;
template <typename T>
using _nrn_mechanism_field = neuron::mechanism::field<T>;
template <typename... Args>
void _nrn_mechanism_register_data_fields(Args&&... args) {
neuron::mechanism::register_data_fields(std::forward<Args>(args)...);
}
}
#if !NRNGPU
#undef exp
#define exp hoc_Exp
#if NRN_ENABLE_ARCH_INDEP_EXP_POW
#undef pow
#define pow hoc_pow
#endif
#endif
#define nrn_init _nrn_init__CaDynamics_E2
#define _nrn_initial _nrn_initial__CaDynamics_E2
#define nrn_cur _nrn_cur__CaDynamics_E2
#define _nrn_current _nrn_current__CaDynamics_E2
#define nrn_jacob _nrn_jacob__CaDynamics_E2
#define nrn_state _nrn_state__CaDynamics_E2
#define _net_receive _net_receive__CaDynamics_E2
#define states states__CaDynamics_E2
#define _threadargscomma_ _ml, _iml, _ppvar, _thread, _globals, _nt,
#define _threadargsprotocomma_ Memb_list* _ml, size_t _iml, Datum* _ppvar, Datum* _thread, double* _globals, NrnThread* _nt,
#define _internalthreadargsprotocomma_ _nrn_mechanism_cache_range* _ml, size_t _iml, Datum* _ppvar, Datum* _thread, double* _globals, NrnThread* _nt,
#define _threadargs_ _ml, _iml, _ppvar, _thread, _globals, _nt
#define _threadargsproto_ Memb_list* _ml, size_t _iml, Datum* _ppvar, Datum* _thread, double* _globals, NrnThread* _nt
#define _internalthreadargsproto_ _nrn_mechanism_cache_range* _ml, size_t _iml, Datum* _ppvar, Datum* _thread, double* _globals, NrnThread* _nt
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *hoc_getarg(int);
#define t _nt->_t
#define dt _nt->_dt
#define gamma _ml->template fpfield<0>(_iml)
#define gamma_columnindex 0
#define decay _ml->template fpfield<1>(_iml)
#define decay_columnindex 1
#define depth _ml->template fpfield<2>(_iml)
#define depth_columnindex 2
#define minCai _ml->template fpfield<3>(_iml)
#define minCai_columnindex 3
#define ica _ml->template fpfield<4>(_iml)
#define ica_columnindex 4
#define cai _ml->template fpfield<5>(_iml)
#define cai_columnindex 5
#define Dcai _ml->template fpfield<6>(_iml)
#define Dcai_columnindex 6
#define v _ml->template fpfield<7>(_iml)
#define v_columnindex 7
#define _g _ml->template fpfield<8>(_iml)
#define _g_columnindex 8
#define _ion_ica *(_ml->dptr_field<0>(_iml))
#define _p_ion_ica static_cast<neuron::container::data_handle<double>>(_ppvar[0])
#define _ion_cao *(_ml->dptr_field<1>(_iml))
#define _p_ion_cao static_cast<neuron::container::data_handle<double>>(_ppvar[1])
#define _ion_cai *(_ml->dptr_field<2>(_iml))
#define _p_ion_cai static_cast<neuron::container::data_handle<double>>(_ppvar[2])
#define _ion_ca_erev *_ml->dptr_field<3>(_iml)
#define _style_ca *_ppvar[4].get<int*>()
/* Thread safe. No static _ml, _iml or _ppvar. */
static int hoc_nrnpointerindex = -1;
static _nrn_mechanism_std_vector<Datum> _extcall_thread;
static Prop* _extcall_prop;
/* _prop_id kind of shadows _extcall_prop to allow validity checking. */
static _nrn_non_owning_id_without_container _prop_id{};
/* external NEURON variables */
/* declaration of user functions */
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
#define NMODL_TEXT 1
#if NMODL_TEXT
static void register_nmodl_text_and_filename(int mechtype);
#endif
static void _hoc_setdata();
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
{"setdata_CaDynamics_E2", _hoc_setdata},
{0, 0}
};
/* Direct Python call wrappers to density mechanism functions.*/
static NPyDirectMechFunc npy_direct_func_proc[] = {
{0, 0}
};
/* declare global and static user variables */
#define gind 0
#define _gth 0
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
{0, 0, 0}
};
static HocParmUnits _hoc_parm_units[] = {
{"decay_CaDynamics_E2", "ms"},
{"depth_CaDynamics_E2", "um"},
{"minCai_CaDynamics_E2", "mM"},
{0, 0}
};
static double cai0 = 0;
static double delta_t = 0.01;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
{0, 0}
};
static DoubVec hoc_vdoub[] = {
{0, 0, 0}
};
static double _sav_indep;
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_extcall_prop = _prop;
_prop_id = _nrn_get_prop_id(_prop);
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
static void nrn_alloc(Prop*);
static void nrn_init(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int);
static void nrn_state(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int);
static void nrn_cur(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int);
static void nrn_jacob(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int);
static int _ode_count(int);
static void _ode_map(Prop*, int, neuron::container::data_handle<double>*, neuron::container::data_handle<double>*, double*, int);
static void _ode_spec(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int);
static void _ode_matsol(_nrn_model_sorted_token const&, NrnThread*, Memb_list*, int);
#define _cvode_ieq _ppvar[5].literal_value<int>()
static void _ode_matsol_instance1(_internalthreadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"CaDynamics_E2",
"gamma_CaDynamics_E2",
"decay_CaDynamics_E2",
"depth_CaDynamics_E2",
"minCai_CaDynamics_E2",
0,
0,
0,
0};
static Symbol* _ca_sym;
/* Used by NrnProperty */
static _nrn_mechanism_std_vector<double> _parm_default{
0.001734, /* gamma */
103.091, /* decay */
0.1, /* depth */
0.0001, /* minCai */
};
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion{};
Datum *_ppvar{};
_ppvar = nrn_prop_datum_alloc(_mechtype, 6, _prop);
_nrn_mechanism_access_dparam(_prop) = _ppvar;
_nrn_mechanism_cache_instance _ml_real{_prop};
auto* const _ml = &_ml_real;
size_t const _iml{};
assert(_nrn_mechanism_get_num_vars(_prop) == 9);
/*initialize range parameters*/
gamma = _parm_default[0]; /* 0.001734 */
decay = _parm_default[1]; /* 103.091 */
depth = _parm_default[2]; /* 0.1 */
minCai = _parm_default[3]; /* 0.0001 */
assert(_nrn_mechanism_get_num_vars(_prop) == 9);
_nrn_mechanism_access_dparam(_prop) = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_ca_sym);
nrn_check_conc_write(_prop, prop_ion, 1);
nrn_promote(prop_ion, 3, 0);
_ppvar[0] = _nrn_mechanism_get_param_handle(prop_ion, 3); /* ica */
_ppvar[1] = _nrn_mechanism_get_param_handle(prop_ion, 2); /* cao */
_ppvar[2] = _nrn_mechanism_get_param_handle(prop_ion, 1); /* cai */
_ppvar[3] = _nrn_mechanism_get_param_handle(prop_ion, 0); // erev ca
_ppvar[4] = {neuron::container::do_not_search, &(_nrn_mechanism_access_dparam(prop_ion)[0].literal_value<int>())}; /* iontype for ca */
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
{0, 0}
};
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
void _nrn_thread_table_reg(int, nrn_thread_table_check_t);
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
extern "C" void _CaDynamics_E2_reg() {
int _vectorized = 1;
_initlists();
ion_reg("ca", -10000.);
_ca_sym = hoc_lookup("ca_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1);
_mechtype = nrn_get_mechtype(_mechanism[1]);
hoc_register_parm_default(_mechtype, &_parm_default);
hoc_register_npy_direct(_mechtype, npy_direct_func_proc);
_nrn_setdata_reg(_mechtype, _setdata);
#if NMODL_TEXT
register_nmodl_text_and_filename(_mechtype);
#endif
_nrn_mechanism_register_data_fields(_mechtype,
_nrn_mechanism_field<double>{"gamma"} /* 0 */,
_nrn_mechanism_field<double>{"decay"} /* 1 */,
_nrn_mechanism_field<double>{"depth"} /* 2 */,
_nrn_mechanism_field<double>{"minCai"} /* 3 */,
_nrn_mechanism_field<double>{"ica"} /* 4 */,
_nrn_mechanism_field<double>{"cai"} /* 5 */,
_nrn_mechanism_field<double>{"Dcai"} /* 6 */,
_nrn_mechanism_field<double>{"v"} /* 7 */,
_nrn_mechanism_field<double>{"_g"} /* 8 */,
_nrn_mechanism_field<double*>{"_ion_ica", "ca_ion"} /* 0 */,
_nrn_mechanism_field<double*>{"_ion_cao", "ca_ion"} /* 1 */,
_nrn_mechanism_field<double*>{"_ion_cai", "ca_ion"} /* 2 */,
_nrn_mechanism_field<double*>{"_ion_ca_erev", "ca_ion"} /* 3 */,
_nrn_mechanism_field<int*>{"_style_ca", "#ca_ion"} /* 4 */,
_nrn_mechanism_field<int>{"_cvode_ieq", "cvodeieq"} /* 5 */);
hoc_register_prop_size(_mechtype, 9, 6);
hoc_register_dparam_semantics(_mechtype, 0, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 1, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 2, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 3, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 4, "#ca_ion");
hoc_register_dparam_semantics(_mechtype, 5, "cvodeieq");
nrn_writes_conc(_mechtype, 0);
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 CaDynamics_E2 /home/qh4os/neurenv/mech/CaDynamics_E2.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static double FARADAY = 0x1.78e555060882cp+16;
static int _reset;
static const char *modelname = "";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int _ode_spec1(_internalthreadargsproto_);
/*static int _ode_matsol1(_internalthreadargsproto_);*/
static neuron::container::field_index _slist1[1], _dlist1[1];
static int states(_internalthreadargsproto_);
/*CVODE*/
static int _ode_spec1 (_internalthreadargsproto_) {int _reset = 0; {
Dcai = - ( 10000.0 ) * ( ica * gamma / ( 2.0 * FARADAY * depth ) ) - ( cai - minCai ) / decay ;
}
return _reset;
}
static int _ode_matsol1 (_internalthreadargsproto_) {
Dcai = Dcai / (1. - dt*( ( - ( ( 1.0 ) ) / decay ) )) ;
return 0;
}
/*END CVODE*/
static int states (_internalthreadargsproto_) { {
cai = cai + (1. - exp(dt*(( - ( ( 1.0 ) ) / decay ))))*(- ( ( - ( 10000.0 ) )*( ( ( ( ica )*( gamma ) ) / ( 2.0 * FARADAY * depth ) ) ) - ( ( ( - minCai ) ) ) / decay ) / ( ( - ( ( 1.0 ) ) / decay ) ) - cai) ;
}
return 0;
}
static int _ode_count(int _type){ return 1;}
static void _ode_spec(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type) {
Datum* _ppvar;
size_t _iml; _nrn_mechanism_cache_range* _ml; Node* _nd{};
double _v{};
int _cntml;
_nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type};
_ml = &_lmr;
_cntml = _ml_arg->_nodecount;
Datum *_thread{_ml_arg->_thread};
double* _globals = nullptr;
if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get<double*>(); }
for (_iml = 0; _iml < _cntml; ++_iml) {
_ppvar = _ml_arg->_pdata[_iml];
_nd = _ml_arg->_nodelist[_iml];
v = NODEV(_nd);
ica = _ion_ica;
cai = _ion_cai;
_ode_spec1 (_threadargs_);
_ion_cai = cai;
}}
static void _ode_map(Prop* _prop, int _ieq, neuron::container::data_handle<double>* _pv, neuron::container::data_handle<double>* _pvdot, double* _atol, int _type) {
Datum* _ppvar;
_ppvar = _nrn_mechanism_access_dparam(_prop);
_cvode_ieq = _ieq;
for (int _i=0; _i < 1; ++_i) {
_pv[_i] = _nrn_mechanism_get_param_handle(_prop, _slist1[_i]);
_pvdot[_i] = _nrn_mechanism_get_param_handle(_prop, _dlist1[_i]);
_cvode_abstol(_atollist, _atol, _i);
}
_pv[0] = _p_ion_cai;
}
static void _ode_matsol_instance1(_internalthreadargsproto_) {
_ode_matsol1 (_threadargs_);
}
static void _ode_matsol(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type) {
Datum* _ppvar;
size_t _iml; _nrn_mechanism_cache_range* _ml; Node* _nd{};
double _v{};
int _cntml;
_nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type};
_ml = &_lmr;
_cntml = _ml_arg->_nodecount;
Datum *_thread{_ml_arg->_thread};
double* _globals = nullptr;
if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get<double*>(); }
for (_iml = 0; _iml < _cntml; ++_iml) {
_ppvar = _ml_arg->_pdata[_iml];
_nd = _ml_arg->_nodelist[_iml];
v = NODEV(_nd);
ica = _ion_ica;
cai = _ion_cai;
_ode_matsol_instance1(_threadargs_);
}}
static void initmodel(_internalthreadargsproto_) {
int _i; double _save;{
}
}
static void nrn_init(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type){
_nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type};
auto* const _vec_v = _nt->node_voltage_storage();
auto* const _ml = &_lmr;
Datum* _ppvar; Datum* _thread;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
_ni = _ml_arg->_nodeindices;
_cntml = _ml_arg->_nodecount;
_thread = _ml_arg->_thread;
double* _globals = nullptr;
if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get<double*>(); }
for (_iml = 0; _iml < _cntml; ++_iml) {
_ppvar = _ml_arg->_pdata[_iml];
_v = _vec_v[_ni[_iml]];
v = _v;
ica = _ion_ica;
cai = _ion_cai;
initmodel(_threadargs_);
_ion_cai = cai;
nrn_wrote_conc(_ca_sym, _ion_ca_erev, _ion_cai, _ion_cao, _style_ca);
}
}
static double _nrn_current(_internalthreadargsprotocomma_ double _v) {
double _current=0.; v=_v;
{
} return _current;
}
static void nrn_cur(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type) {
_nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type};
auto const _vec_rhs = _nt->node_rhs_storage();
auto const _vec_sav_rhs = _nt->node_sav_rhs_storage();
auto const _vec_v = _nt->node_voltage_storage();
auto* const _ml = &_lmr;
Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
_ni = _ml_arg->_nodeindices;
_cntml = _ml_arg->_nodecount;
_thread = _ml_arg->_thread;
double* _globals = nullptr;
if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get<double*>(); }
for (_iml = 0; _iml < _cntml; ++_iml) {
_ppvar = _ml_arg->_pdata[_iml];
_v = _vec_v[_ni[_iml]];
}
}
static void nrn_jacob(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type) {
_nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type};
auto const _vec_d = _nt->node_d_storage();
auto const _vec_sav_d = _nt->node_sav_d_storage();
auto* const _ml = &_lmr;
Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; int _iml, _cntml;
_ni = _ml_arg->_nodeindices;
_cntml = _ml_arg->_nodecount;
_thread = _ml_arg->_thread;
double* _globals = nullptr;
if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get<double*>(); }
for (_iml = 0; _iml < _cntml; ++_iml) {
_vec_d[_ni[_iml]] += _g;
}
}
static void nrn_state(_nrn_model_sorted_token const& _sorted_token, NrnThread* _nt, Memb_list* _ml_arg, int _type) {
_nrn_mechanism_cache_range _lmr{_sorted_token, *_nt, *_ml_arg, _type};
auto* const _vec_v = _nt->node_voltage_storage();
auto* const _ml = &_lmr;
Datum* _ppvar; Datum* _thread;
Node *_nd; double _v = 0.0; int* _ni;
_ni = _ml_arg->_nodeindices;
size_t _cntml = _ml_arg->_nodecount;
_thread = _ml_arg->_thread;
double* _globals = nullptr;
if (gind != 0 && _thread != nullptr) { _globals = _thread[_gth].get<double*>(); }
for (size_t _iml = 0; _iml < _cntml; ++_iml) {
_ppvar = _ml_arg->_pdata[_iml];
_nd = _ml_arg->_nodelist[_iml];
_v = _vec_v[_ni[_iml]];
v=_v;
{
ica = _ion_ica;
cai = _ion_cai;
{ states(_threadargs_);
} {
}
_ion_cai = cai;
}}
}
static void terminal(){}
static void _initlists(){
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = {cai_columnindex, 0}; _dlist1[0] = {Dcai_columnindex, 0};
_first = 0;
}
#if NMODL_TEXT
static void register_nmodl_text_and_filename(int mech_type) {
const char* nmodl_filename = "/home/qh4os/neurenv/mech/CaDynamics_E2.mod";
const char* nmodl_file_text =
":Comment : L6\n"
": Dynamics that track inside calcium concentration\n"
": modified from Destexhe et al. 1994\n"
"\n"
"NEURON {\n"
" SUFFIX CaDynamics_E2\n"
" USEION ca READ ica WRITE cai\n"
" RANGE decay, gamma, minCai, depth\n"
"}\n"
"\n"
"UNITS {\n"
" (mV) = (millivolt)\n"
" (mA) = (milliamp)\n"
" FARADAY = (faraday) (coulombs)\n"
" (molar) = (1/liter)\n"
" (mM) = (millimolar)\n"
" (um) = (micron)\n"
"}\n"
"\n"
"PARAMETER {\n"
" gamma = 0.001734 : percent of free calcium (not buffered)\n"
" decay = 103.091390 (ms) : rate of removal of calcium\n"
" depth = 0.1 (um) : depth of shell\n"
" minCai = 1e-4 (mM)\n"
"}\n"
"\n"
"ASSIGNED {ica (mA/cm2)}\n"
"\n"
"STATE {\n"
" cai (mM)\n"
" }\n"
"\n"
"BREAKPOINT { SOLVE states METHOD cnexp }\n"
"\n"
"DERIVATIVE states {\n"
" cai' = -(10000)*(ica*gamma/(2*FARADAY*depth)) - (cai - minCai)/decay\n"
"}\n"
;
hoc_reg_nmodl_filename(mech_type, nmodl_filename);
hoc_reg_nmodl_text(mech_type, nmodl_file_text);
}
#endif