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neurenv/x86_64/hhqt.c
Connell Paxton a0a907245a Added additional files
2026-07-11 18:20:01 -04:00

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/* Created by Language version: 7.7.0 */
/* VECTORIZED */
#define NRN_VECTORIZED 1
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "mech_api.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__hhqt
#define _nrn_initial _nrn_initial__hhqt
#define nrn_cur _nrn_cur__hhqt
#define _nrn_current _nrn_current__hhqt
#define nrn_jacob _nrn_jacob__hhqt
#define nrn_state _nrn_state__hhqt
#define _net_receive _net_receive__hhqt
#define rates rates__hhqt
#define states states__hhqt
#define _threadargscomma_ _p, _ppvar, _thread, _nt,
#define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt,
#define _threadargs_ _p, _ppvar, _thread, _nt
#define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg(int);
/* Thread safe. No static _p or _ppvar. */
#define t _nt->_t
#define dt _nt->_dt
#define gnabar _p[0]
#define gnabar_columnindex 0
#define gkbar _p[1]
#define gkbar_columnindex 1
#define gl _p[2]
#define gl_columnindex 2
#define el _p[3]
#define el_columnindex 3
#define gna _p[4]
#define gna_columnindex 4
#define gk _p[5]
#define gk_columnindex 5
#define il _p[6]
#define il_columnindex 6
#define m _p[7]
#define m_columnindex 7
#define h _p[8]
#define h_columnindex 8
#define n _p[9]
#define n_columnindex 9
#define ena _p[10]
#define ena_columnindex 10
#define ek _p[11]
#define ek_columnindex 11
#define ina _p[12]
#define ina_columnindex 12
#define ik _p[13]
#define ik_columnindex 13
#define minf _p[14]
#define minf_columnindex 14
#define hinf _p[15]
#define hinf_columnindex 15
#define ninf _p[16]
#define ninf_columnindex 16
#define mtau _p[17]
#define mtau_columnindex 17
#define htau _p[18]
#define htau_columnindex 18
#define ntau _p[19]
#define ntau_columnindex 19
#define Dm _p[20]
#define Dm_columnindex 20
#define Dh _p[21]
#define Dh_columnindex 21
#define Dn _p[22]
#define Dn_columnindex 22
#define v _p[23]
#define v_columnindex 23
#define _g _p[24]
#define _g_columnindex 24
#define _ion_ena *_ppvar[0]._pval
#define _ion_ina *_ppvar[1]._pval
#define _ion_dinadv *_ppvar[2]._pval
#define _ion_ek *_ppvar[3]._pval
#define _ion_ik *_ppvar[4]._pval
#define _ion_dikdv *_ppvar[5]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
static Datum* _extcall_thread;
static Prop* _extcall_prop;
/* external NEURON variables */
extern double celsius;
/* declaration of user functions */
static void _hoc_rates(void);
static void _hoc_vtrap(void);
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_extcall_prop = _prop;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_hhqt", _hoc_setdata,
"rates_hhqt", _hoc_rates,
"vtrap_hhqt", _hoc_vtrap,
0, 0
};
#define vtrap vtrap_hhqt
extern double vtrap( _threadargsprotocomma_ double , double );
/* declare global and static user variables */
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
"gl_hhqt", 0, 1e+09,
"gkbar_hhqt", 0, 1e+09,
"gnabar_hhqt", 0, 1e+09,
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"gnabar_hhqt", "S/cm2",
"gkbar_hhqt", "S/cm2",
"gl_hhqt", "S/cm2",
"el_hhqt", "mV",
"gna_hhqt", "S/cm2",
"gk_hhqt", "S/cm2",
"il_hhqt", "mA/cm2",
0,0
};
static double delta_t = 0.01;
static double h0 = 0;
static double m0 = 0;
static double n0 = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(NrnThread*, _Memb_list*, int);
static void nrn_state(NrnThread*, _Memb_list*, int);
static void nrn_cur(NrnThread*, _Memb_list*, int);
static void nrn_jacob(NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(NrnThread*, _Memb_list*, int);
static void _ode_matsol(NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[6]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"hhqt",
"gnabar_hhqt",
"gkbar_hhqt",
"gl_hhqt",
"el_hhqt",
0,
"gna_hhqt",
"gk_hhqt",
"il_hhqt",
0,
"m_hhqt",
"h_hhqt",
"n_hhqt",
0,
0};
static Symbol* _na_sym;
static Symbol* _k_sym;
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 25, _prop);
/*initialize range parameters*/
gnabar = 0.12;
gkbar = 0.036;
gl = 0.0003;
el = -54.3;
_prop->param = _p;
_prop->param_size = 25;
_ppvar = nrn_prop_datum_alloc(_mechtype, 7, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_na_sym);
nrn_promote(prop_ion, 0, 1);
_ppvar[0]._pval = &prop_ion->param[0]; /* ena */
_ppvar[1]._pval = &prop_ion->param[3]; /* ina */
_ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dinadv */
prop_ion = need_memb(_k_sym);
nrn_promote(prop_ion, 0, 1);
_ppvar[3]._pval = &prop_ion->param[0]; /* ek */
_ppvar[4]._pval = &prop_ion->param[3]; /* ik */
_ppvar[5]._pval = &prop_ion->param[4]; /* _ion_dikdv */
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
static void _update_ion_pointer(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _hhqt_reg() {
int _vectorized = 1;
_initlists();
ion_reg("na", -10000.);
ion_reg("k", -10000.);
_na_sym = hoc_lookup("na_ion");
_k_sym = hoc_lookup("k_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
#if NMODL_TEXT
hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
hoc_register_prop_size(_mechtype, 25, 7);
hoc_register_dparam_semantics(_mechtype, 0, "na_ion");
hoc_register_dparam_semantics(_mechtype, 1, "na_ion");
hoc_register_dparam_semantics(_mechtype, 2, "na_ion");
hoc_register_dparam_semantics(_mechtype, 3, "k_ion");
hoc_register_dparam_semantics(_mechtype, 4, "k_ion");
hoc_register_dparam_semantics(_mechtype, 5, "k_ion");
hoc_register_dparam_semantics(_mechtype, 6, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 hhqt /home/qh4os/neurenv/mech/hhqt.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rates(_threadargsprotocomma_ double);
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[3], _dlist1[3];
static int states(_threadargsproto_);
/*CVODE*/
static int _ode_spec1 (double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) {int _reset = 0; {
rates ( _threadargscomma_ v ) ;
Dm = ( minf - m ) / mtau ;
Dh = ( hinf - h ) / htau ;
Dn = ( ninf - n ) / ntau ;
}
return _reset;
}
static int _ode_matsol1 (double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) {
rates ( _threadargscomma_ v ) ;
Dm = Dm / (1. - dt*( ( ( ( - 1.0 ) ) ) / mtau )) ;
Dh = Dh / (1. - dt*( ( ( ( - 1.0 ) ) ) / htau )) ;
Dn = Dn / (1. - dt*( ( ( ( - 1.0 ) ) ) / ntau )) ;
return 0;
}
/*END CVODE*/
static int states (double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) { {
rates ( _threadargscomma_ v ) ;
m = m + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / mtau)))*(- ( ( ( minf ) ) / mtau ) / ( ( ( ( - 1.0 ) ) ) / mtau ) - m) ;
h = h + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / htau)))*(- ( ( ( hinf ) ) / htau ) / ( ( ( ( - 1.0 ) ) ) / htau ) - h) ;
n = n + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / ntau)))*(- ( ( ( ninf ) ) / ntau ) / ( ( ( ( - 1.0 ) ) ) / ntau ) - n) ;
}
return 0;
}
static int rates ( _threadargsprotocomma_ double _lv ) {
double _lalpha , _lbeta , _lsum , _lq10 ;
_lq10 = pow( 3.0 , ( ( celsius - 6.3 ) / 10.0 ) ) ;
_lalpha = .1 * vtrap ( _threadargscomma_ - ( _lv + 40.0 ) , 10.0 ) ;
_lbeta = 4.0 * exp ( - ( _lv + 65.0 ) / 18.0 ) ;
_lsum = _lalpha + _lbeta ;
mtau = 1.0 / ( _lq10 * _lsum ) ;
minf = _lalpha / _lsum ;
_lalpha = .07 * exp ( - ( _lv + 65.0 ) / 20.0 ) ;
_lbeta = 1.0 / ( exp ( - ( _lv + 35.0 ) / 10.0 ) + 1.0 ) ;
_lsum = _lalpha + _lbeta ;
htau = 1.0 / ( _lq10 * _lsum ) ;
hinf = _lalpha / _lsum ;
_lalpha = .01 * vtrap ( _threadargscomma_ - ( _lv + 55.0 ) , 10.0 ) ;
_lbeta = .125 * exp ( - ( _lv + 65.0 ) / 80.0 ) ;
_lsum = _lalpha + _lbeta ;
ntau = 1.0 / ( _lq10 * _lsum ) ;
ninf = _lalpha / _lsum ;
return 0; }
static void _hoc_rates(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = 1.;
rates ( _p, _ppvar, _thread, _nt, *getarg(1) );
hoc_retpushx(_r);
}
double vtrap ( _threadargsprotocomma_ double _lx , double _ly ) {
double _lvtrap;
if ( fabs ( _lx / _ly ) < 1e-6 ) {
_lvtrap = _ly * ( 1.0 - _lx / _ly / 2.0 ) ;
}
else {
_lvtrap = _lx / ( exp ( _lx / _ly ) - 1.0 ) ;
}
return _lvtrap;
}
static void _hoc_vtrap(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = vtrap ( _p, _ppvar, _thread, _nt, *getarg(1) , *getarg(2) );
hoc_retpushx(_r);
}
static int _ode_count(int _type){ return 3;}
static void _ode_spec(NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ena = _ion_ena;
ek = _ion_ek;
_ode_spec1 (_p, _ppvar, _thread, _nt);
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
double* _p; Datum* _ppvar;
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 3; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 (_p, _ppvar, _thread, _nt);
}
static void _ode_matsol(NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ena = _ion_ena;
ek = _ion_ek;
_ode_matsol_instance1(_threadargs_);
}}
extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
static void _update_ion_pointer(Datum* _ppvar) {
nrn_update_ion_pointer(_na_sym, _ppvar, 0, 0);
nrn_update_ion_pointer(_na_sym, _ppvar, 1, 3);
nrn_update_ion_pointer(_na_sym, _ppvar, 2, 4);
nrn_update_ion_pointer(_k_sym, _ppvar, 3, 0);
nrn_update_ion_pointer(_k_sym, _ppvar, 4, 3);
nrn_update_ion_pointer(_k_sym, _ppvar, 5, 4);
}
static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt) {
int _i; double _save;{
h = h0;
m = m0;
n = n0;
{
rates ( _threadargscomma_ v ) ;
m = minf ;
h = hinf ;
n = ninf ;
}
}
}
static void nrn_init(NrnThread* _nt, _Memb_list* _ml, int _type){
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
ena = _ion_ena;
ek = _ion_ek;
initmodel(_p, _ppvar, _thread, _nt);
}
}
static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, NrnThread* _nt, double _v){double _current=0.;v=_v;{ {
gna = gnabar * m * m * m * h ;
ina = gna * ( v - ena ) ;
gk = gkbar * n * n * n * n ;
ik = gk * ( v - ek ) ;
il = gl * ( v - el ) ;
}
_current += ina;
_current += ik;
_current += il;
} return _current;
}
static void nrn_cur(NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
ena = _ion_ena;
ek = _ion_ek;
_g = _nrn_current(_p, _ppvar, _thread, _nt, _v + .001);
{ double _dik;
double _dina;
_dina = ina;
_dik = ik;
_rhs = _nrn_current(_p, _ppvar, _thread, _nt, _v);
_ion_dinadv += (_dina - ina)/.001 ;
_ion_dikdv += (_dik - ik)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ina += ina ;
_ion_ik += ik ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}
}
static void nrn_jacob(NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}
}
static void nrn_state(NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
ena = _ion_ena;
ek = _ion_ek;
{ states(_p, _ppvar, _thread, _nt);
} }}
}
static void terminal(){}
static void _initlists(){
double _x; double* _p = &_x;
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = m_columnindex; _dlist1[0] = Dm_columnindex;
_slist1[1] = h_columnindex; _dlist1[1] = Dh_columnindex;
_slist1[2] = n_columnindex; _dlist1[2] = Dn_columnindex;
_first = 0;
}
#if defined(__cplusplus)
} /* extern "C" */
#endif
#if NMODL_TEXT
static const char* nmodl_filename = "/home/qh4os/neurenv/mech/hhqt.mod";
static const char* nmodl_file_text =
"COMMENT\n"
" This is the original Hodgkin-Huxley treatment for the set of sodium, \n"
" potassium, and leakage channels found in the squid giant axon membrane.\n"
" (\"A quantitative description of membrane current and its application \n"
" conduction and excitation in nerve\" J.Physiol. (Lond.) 117:500-544 (1952).)\n"
" Membrane voltage is in absolute mV and has been reversed in polarity\n"
" from the original HH convention and shifted to reflect a resting potential\n"
" of -65 mV.\n"
" Remember to set a squid-appropriate temperature\n"
" (e.g. in HOC: \"celsius=6.3\" or in Python: \"h.celsius=6.3\").\n"
" See squid.hoc for an example of a simulation using this model.\n"
" SW Jaslove 6 March, 1992\n"
"ENDCOMMENT\n"
"\n"
"NEURON {\n"
" SUFFIX hhqt\n"
" USEION na READ ena WRITE ina\n"
" USEION k READ ek WRITE ik\n"
" NONSPECIFIC_CURRENT il\n"
" RANGE gnabar, gkbar, gl, el, gna, gk\n"
"}\n"
" \n"
"UNITS {\n"
" (mA) = (milliamp)\n"
" (mV) = (millivolt)\n"
" (S) = (siemens)\n"
"}\n"
" \n"
"PARAMETER {\n"
" gnabar = .12 (S/cm2) <0,1e9>\n"
" gkbar = .036 (S/cm2) <0,1e9>\n"
" gl = .0003 (S/cm2) <0,1e9>\n"
" el = -54.3 (mV)\n"
"}\n"
" \n"
"ASSIGNED {\n"
" v (mV)\n"
" ena (mV)\n"
" ek (mV)\n"
" gna (S/cm2)\n"
" gk (S/cm2)\n"
" ina (mA/cm2)\n"
" ik (mA/cm2)\n"
" il (mA/cm2)\n"
" minf hinf ninf\n"
" mtau (ms) htau (ms) ntau (ms)\n"
" celsius (degC)\n"
"}\n"
" \n"
"STATE {\n"
" m h n\n"
"}\n"
" \n"
"BREAKPOINT {\n"
" SOLVE states METHOD cnexp\n"
" gna = gnabar*m*m*m*h\n"
" ina = gna*(v - ena)\n"
" gk = gkbar*n*n*n*n\n"
" ik = gk*(v - ek) \n"
" il = gl*(v - el)\n"
"}\n"
"\n"
"DERIVATIVE states { \n"
" rates(v)\n"
" m' = (minf-m)/mtau\n"
" h' = (hinf-h)/htau\n"
" n' = (ninf-n)/ntau\n"
"}\n"
" \n"
"INITIAL {\n"
" rates(v)\n"
" m = minf\n"
" h = hinf\n"
" n = ninf\n"
"}\n"
"\n"
"PROCEDURE rates(v(mV)) { :Computes rate and other constants at current v.\n"
" :Call once from HOC to initialize inf at resting v.\n"
" LOCAL alpha, beta, sum, q10\n"
" q10 = 3^((celsius - 6.3)/10)\n"
"\n"
"UNITSOFF\n"
" :\"m\" sodium activation system\n"
" alpha = .1*vtrap(-(v+40),10)\n"
" beta = 4*exp(-(v+65)/18)\n"
" sum = alpha + beta\n"
" mtau = 1/(q10*sum)\n"
" minf = alpha/sum\n"
" \n"
" :\"h\" sodium inactivation system\n"
" alpha = .07*exp(-(v+65)/20)\n"
" beta = 1/(exp(-(v+35)/10) + 1)\n"
" sum = alpha + beta\n"
" htau = 1/(q10*sum)\n"
" hinf = alpha/sum\n"
" \n"
" :\"n\" potassium activation system\n"
" alpha = .01*vtrap(-(v+55),10) \n"
" beta = .125*exp(-(v+65)/80)\n"
" sum = alpha + beta\n"
" ntau = 1/(q10*sum)\n"
" ninf = alpha/sum\n"
"}\n"
" \n"
"FUNCTION vtrap(x,y) { :Traps for 0 in denominator of rate eqns.\n"
" if (fabs(x/y) < 1e-6) {\n"
" vtrap = y*(1 - x/y/2)\n"
" }else{\n"
" vtrap = x/(exp(x/y) - 1)\n"
" }\n"
"}\n"
" \n"
"UNITSON\n"
;
#endif
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